Angiopoietin-like Protein 2

Angiopoietin-like Protein 2 (ANGPTL2), also known as ARP2 is a secreted glycoprotein that contains a N-terminal coiled coil domain and a C-terminal fibrinogen like domain. ANGPTL2 has both pro and anti-angiogenic functions. It serves as tumor suppressor in ovarian cancer, and also promote metastasis in various cancer types, making it potential biomarker for tumor progression. ANGPTL2 also function as growth factor to enhance the survival of hematopoietic progenitors, mediated by its coiled coil domain. Receptor of ANGPTL2 is recently identified as LILRB2, and both the coiled coil domain and fibrinogen like domain are required for optimal binding.